Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Tandara L, Salamunic I. Managing coronary artery disease in the cancer patient.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Post-discharge health care needs of patients after lung cancer resection. Thalidomide and dexamethasone for resistant multiple myeloma. As we have reviewed in the present paper, no mechanism seems capable by itself of causing the whole clinical picture.

The expression of these cytokines has been shown to have a relevant cardiotooxicidad in cardiotoxicity induced by anthracyclines, mainly by modulating apoptosis through TNF receptors, whose function is affected by doxorubicin.

Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy. The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats.

Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: Risk of thrombosis with lenalidomide and its prevention with aspirin. Anthracycline toxicity seems to be a multistep and multifactorial condition, with complex pathophysiology and requiring a multidisciplinary approach. Conclusions With the improvements in early diagnosis and anti-tumoral treatments, we are witnessing an increased survival in oncologic patients.


Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule cardiotosicidad in human umbilical vein endothelial cells.

Miocardiopatía inducida por antraciclinas: conocimientos moleculares básicos para el cardiólogo

The two most representative drugs are doxorubicin and daunorubicin and they have been proven as useful antineoplastics and are widely prescribed in daily oncology practice; unfortunately, cardiotoxicity has been a limiting factor when it comes to their use.

Energy metabolism in heart failure. Medina PJ, Goodin S. Doxorubicin and paclitaxel in advanced breast carcinoma: Anthracyclines, such as doxorubicin, and monoclonal antibodies, such as trastuzumab, are compounds of wide clinical use as cytotoxic chemotherapy as they significantly reduce cancer-related mortality.

Predicting and preventing cardiotoxicity in the era antrqciclinas breast cancer targeted antraciclknas. Likewise, animal models have shown that iron overload is capable of potentiating doxorubicin cardiotoxicity by mechanisms other than ROS production. Phase I trial of the proteasome inhibitor PS in patients with refractory hematologic malignancies. Anthracyclines are capable of promoting proinflammatory cytokines release, which has been related to several manifestations ranging from cardiotoxicity to asthenia experienced by these patients.

Minimizing cardiotoxicity while optimizing treatment efficacy with trastuzumab: Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy.

Pathology of drug-eluting stents in humans: Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity. Cardiac disturbances during the administration of taxol. Cardiotoxicity of cytotoxic drugs. Am J Clin Pathol.


Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Ischemic heart disease associated with vincristine and doxorubicin chemotherapy. Review role of topotecan in gynaecological cancers: Acute myocardial infarction and cardiac arrest in a patient receiving paclitaxel. Interactions between doxorubicin and the human iron regulatory system. Karnofsky performance status revisited: The patient developed heart rhythm disturbances that lead to sudden death after slow intravenous infusion of doxorubicin.

J Interferon Cytokine Res. Quality of life in long-term, disease-free survivors of breast cancer: Nat Clin Pract Oncol. Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab.

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

However, the toxicity is a major adverse effect of these agents, which may occur at any time xntraciclinas their administration or afterwards, especially when used in combination. Herceptin and the heart – a molecular modifier of cardiac failure.

Cardiopulmonary exercise testing in the evaluation of high risk patients with lung cancer. Role of anthracyclines in the era of targeted therapy.

Cardiovascular effects of systemic cancer treatment. Se unen al acido desoxirribonucleico e interfieren en la sintesis de acidos nucleicos. Mertens 47 Estimated H-index: