The Milan criteria are a generally accepted set of criteria used to assess suitability in patients for liver transplantation with cirrhosis and hepatocellular carcinoma. Avaliação do tratamento dos nódulos do hepatocarcinoma nos pacientes em lista entre pacientes incluídos no Critério de Milão ou ao downstaging (p= 0,). .. Yan L. Downstaging advanced hepatocellular carcinoma to the Milan criteria. Catorze diferentes critérios foram encontrados e descritos em detalhes. The keywords used were hepatocellular carcinoma, liver transplantation, expanded.

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The surgical approach to HCC: The first description was published in by the group of the University of California The challenges of liver transplantation for hepatocellular carcinoma on cirrhosis.

Treatment strategy for small hepatocellular criterio Surg Oncol ; The data collected were based on the online database PubMED. Hepatocellular carcinoma locoregional therapies for patients in the waiting list. Our data indicated that LDLT was performed more frequently in the Milan criteria group, so this selective bias did not affect the long-term survival rate. All of the donations were voluntary and altruistic. Author information Article notes Copyright and License information Disclaimer.

Appendicectomy Colectomy Colonic polypectomy Colostomy Hartmann’s operation. All of the data were managed and analyzed using SPSS Liver transplantation outcomes in 1, hepatocellular carcinoma patients: Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. InYao et al. Finally, the societal benefit of expanding tumor criteria needs to be weighed against a relatively fixed donor organ supply and a growing demand for OLT for other indications, such as decompensated cirrhosis due to chronic hepatitis C, where long-term survival may be better.


Peer review This is an interesting study comparing liver transplant outcomes in 3 groups of patients with different stage of HCC. For grafts that came from living donors, the donor was required to be within three degrees of consanguinity with the recipient, as verified by a DNA test, and all of the living donor liver transplantations were performed after obtaining approval from the Ethics Committee of the West China Hospital and local authorities.

Milan criteria – Wikipedia

Adult living donor liver transplantation for patients milann hepatocellular carcinoma extending UNOS priority criteria. Predicting survival after liver transplantation using up-to-seven criteria in patients with hepatocellular carcinoma. Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellular carcinoma.

All of these patients were diagnosed with HCC based on pre-operative imaging studies, and the diagnoses were confirmed by pathology. N Engl J Med ; Takada Y, Uemoto S.

Milan criteria

mialn Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors. A future randomized study would be the best way to evaluate the effectiveness of the up-to-seven criteria as inclusion criteria for HCC LT. Morphological features of advanced hepatocellular carcinoma as a predictor of downstaging and liver transplantation: Grupo com tratamento submetidos ao tratamento loco-regional e Grupo sem tratamento sem tratamento loco-regional.

However, this ideal design would be very difficult to implement due to logistical challenges. Some have hhepatocarcinoma for the use of expanded guidelines for liver transplantation in the setting of HCC. Impact on transplantability and recurrence rate. Frey’s procedure Pancreas transplantation Pancreatectomy Pancreaticoduodenectomy Puestow procedure.

Our Milan criteria patients exhibited a The length of follow-up for all the patients in our study was at least 5 years, and no significant differences were observed among the groups.


Liver transplantation outcomes in 1, hepatocellular carcinoma patients: Only tumor-related deaths were included in the recurrence-free survival analysis. All of these donations were volunteered by the donor or the family.

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Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: Although few reports have suggested that tumor involvement in the portal branches is a contraindication for LT[ 2627 ], there is general agreement among various researchers that patients presenting macrovascular invasion or extrahepatic spread should be excluded from LT given the unacceptable rate of recurrence[ 10 ]; this presumption was confirmed by our analysis, which showed a very high recurrence rate Nineteen papers were excluded due to: This study analyzes the natural history of HCC in patients older than 75, and determines factors that condition their survival.

Analysis of long-term outcomes of liver transplantations over two decades: Some published papers[ 25 ] have even indicated that early graft regeneration and features specific to living-donor liver transplantation LDLT may adversely influence the recurrence of HCC.

Hospital Universitario 12 de Octubre.

Adriano Miziara Gonzalez E-mail: We compiled data focusing on patient survival rate and tumor recurrence free rate from 1 to 5-years. Undertreatment strongly decreases prognosis of breast cancer in elderly women.

European Association for the Study of the Liver. Survival and tumor recurrence. Table 2 Site of hepatocellular carcinoma recurrence or metastasis after liver transplantation. J Hepatobiliary Pancreat Sci. Hepatocellular carcinoma in extremely elderly patients: