FARMACEVTSKA TEHNOLOGIJA PDF

Feature: for medium temperatures > °C or frequent changes in temperature. 0 to 1 bar – 0 to 60 bar relative, 0 to 1 bar – 0 to 25 bar absolute; Medium. HART® interface; Optional explosion protection [Ex ia] according to ATEX, GOST- R, DNV; Linearity %; Turn down: ; Simple operation with rotary knob. Get this from a library! Farmacevtska tehnologija. Del 1, Praktikum. [Julijana Kristl ; Jelka Šmid-Korbar; Stanko Srčič].

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Pellet coating is commonly performed in a fluid bed coater such as a Wurster coater.

The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production. Javascript is necessary for the proper functioning of this website.

Farmacevtska tehnologija: Praktikum. Del 1

Your browser does not allow JavaScript! Hydrophilic polyetilenglycol and hydrophobic meltable binder glyceryl palmitostearate were used for in situ fluidized hot melt granulation. Computational fluid dynamics CFD simulations and experimental measurements of laboratory-scale Wurster coating were performed. Your browser does not allow JavaScript!

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Farmacevtska tehnologija: za studii i praktika – Angel Simov – Google Books

Granule shape was affected by interplay of binder content, binder particle size and granulation time. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate.

The results obtained indicate that conventional fluid bedgranulator may be suitable for production of highly spherical agglomerates,particularly when immersion and layering is dominant agglomeration mechanism. Voting is allowed only to logged tehnologiia users. You have to log in to leave a comment. Voting is allowed only to logged in users. CFD simulations were performed in a 2D axisymmetric space using the two-fluid model. Please enable JavaScript or use a modern browser.

Please enable JavaScript or use a modern browser. URL – Presentation file, Visit http: You have to log in to leave a comment. Binder content was shown to be important for narrow size distribution and goodflow properties. A rather good agreement between the simulated and experimental results was observed and thus it can be assumeed that this particular simulation setup represents a computationally reasonable tool that provides a valuable insight into the Wurster coating process due to the impact of two-phase flow properties on the process.

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Granule size was mainly influenced by binder particle size. Solid state analysis confirmed unaltered physical state of the granulate components and the absenceof interactions between the active and excipients.

Experimentally, the draft tube two-phase flow was evaluated by measuring the volume fraction of pellets within the draft tube and local particle velocities at the tube exit and by monitoring the local pressure drop fluctuations. The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule sizeand size distribution, granule shape and flowability, as well as on drug release rate.

URL – Presentation file, Visit http: The effect of the Wurster gap and fluidizing air flow rate on gas-solidflow was analyzed in both simulations and experiments. Javascript is necessary for the proper functioning of this website.